Hans Clevers Selected Research

Multiple Myeloma

1/2018	Syndecan-1 promotes Wnt/β-catenin signaling in multiple myeloma by presenting Wnts and R-spondins.
10/2017	Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins.

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Hans Clevers Research Topics

Disease

117	Neoplasms (Cancer) 04/2024 - 02/2002
45	Colorectal Neoplasms (Colorectal Cancer) 03/2024 - 02/2002
19	Adenoma (Adenomas) 11/2023 - 09/2002
14	Carcinogenesis 01/2024 - 09/2002
10	Adenomatous Polyposis Coli (Familial Adenomatous Polyposis) 04/2015 - 02/2002
9	Carcinoma (Carcinomatosis) 01/2024 - 09/2002
9	Infections 01/2024 - 01/2018
9	Breast Neoplasms (Breast Cancer) 11/2023 - 05/2010
9	Inflammation (Inflammations) 01/2023 - 09/2007
8	Colonic Neoplasms (Colon Cancer) 01/2023 - 11/2005
8	Cystic Fibrosis (Mucoviscidosis) 10/2021 - 07/2013
5	Neoplasm Metastasis (Metastasis) 01/2024 - 10/2018
5	Pancreatic Neoplasms (Pancreatic Cancer) 12/2020 - 10/2011
4	Hyperplasia 02/2024 - 03/2009
4	Adenocarcinoma 11/2022 - 10/2011
3	Stomach Neoplasms (Stomach Cancer) 04/2024 - 06/2014
3	Rectal Neoplasms (Rectal Cancer) 01/2023 - 10/2019
3	Disease Progression 11/2022 - 11/2020
3	Squamous Cell Carcinoma of Head and Neck 10/2020 - 01/2019
2	Head and Neck Neoplasms (Head and Neck Cancer) 12/2023 - 11/2019
2	Liver Neoplasms (Liver Cancer) 01/2023 - 01/2022
2	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2022 - 09/2014
2	Hepatocellular Carcinoma (Hepatoma) 01/2021 - 10/2018
2	Crohn Disease (Crohn's Disease) 01/2021 - 09/2007
2	Body Weight (Weight, Body) 01/2020 - 01/2011
2	Chromosomal Instability (Chromosome Stability) 01/2019 - 02/2005
2	Influenza in Birds (Avian Flu) 11/2018 - 01/2018
2	Multiple Myeloma 01/2018 - 10/2017
2	Dry Eye Syndromes (Dry Eye Syndrome) 05/2017 - 07/2013
2	Leukemia 02/2017 - 11/2010
2	Polyps 01/2017 - 05/2002
2	Prostatic Neoplasms (Prostate Cancer) 02/2016 - 09/2014
2	Diarrhea 10/2015 - 01/2011
2	Microvillus inclusion disease 10/2015 - 07/2014
2	Type 2 Diabetes Mellitus (MODY) 01/2015 - 12/2012

Drug/Important Bio-Agent (IBA)

28	Proteins (Proteins, Gene)FDA Link 04/2024 - 02/2002
24	beta CateninIBA 03/2010 - 02/2002
15	CateninsIBA 02/2024 - 10/2010
13	LigandsIBA 11/2023 - 10/2002
9	Biomarkers (Surrogate Marker)IBA 12/2023 - 12/2010
6	DNA (Deoxyribonucleic Acid)IBA 12/2023 - 01/2014
6	Phosphotransferases (Kinase)IBA 01/2020 - 04/2009
5	ChromatinIBA 02/2024 - 04/2008
5	Phenobarbital (Luminal)FDA Link 11/2023 - 05/2010
5	TCF Transcription FactorsIBA 12/2007 - 04/2002
4	ErbB Receptors (EGF Receptor)IBA 03/2024 - 10/2017
4	RNA (Ribonucleic Acid)IBA 01/2024 - 01/2020
4	Hormones (Hormone)IBA 12/2021 - 11/2018
4	Estrogen ReceptorsIBA 01/2021 - 06/2014
4	ColforsinIBA 01/2020 - 07/2013
4	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA 01/2018 - 07/2013
4	Transcription Factors (Transcription Factor)IBA 09/2014 - 07/2003
4	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 03/2014 - 02/2002
3	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 03/2024 - 01/2016
3	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 02/2024 - 10/2018
3	EnzymesIBA 11/2023 - 07/2012
3	Irinotecan (Camptosar)FDA LinkGeneric 01/2023 - 07/2011
3	Messenger RNA (mRNA)IBA 01/2023 - 02/2002
3	CytokinesIBA 01/2022 - 11/2018
3	Protein Isoforms (Isoforms)IBA 10/2017 - 10/2011
3	Calcibiotic Root Canal SealerIBA 01/2017 - 04/2014
3	Leucine (L-Leucine)FDA Link 06/2015 - 05/2010
2	Cadherins (E-Cadherin)IBA 04/2024 - 01/2006
2	colibactinIBA 03/2024 - 01/2020
2	ActomyosinIBA 02/2024 - 06/2011
2	AntigensIBA 11/2023 - 05/2017
2	Indicators and Reagents (Reagents)IBA 11/2023 - 10/2011
2	Fatty Acids (Saturated Fatty Acids)IBA 11/2023 - 11/2023
2	Epidermal Growth Factor (EGF)IBA 01/2023 - 10/2017
2	Fluorouracil (Carac)FDA LinkGeneric 10/2022 - 10/2020
2	Glucose (Dextrose)FDA LinkGeneric 10/2022 - 01/2015
2	Bispecific AntibodiesIBA 01/2022 - 01/2022
2	MucinsIBA 01/2022 - 07/2013
2	Adenine FDA LinkGeneric 10/2021 - 01/2020
2	Peptides (Polypeptides)IBA 01/2021 - 10/2020
2	Progesterone Receptors (Progesterone Receptor)IBA 01/2021 - 01/2020
2	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 12/2020 - 09/2002
2	Insulin (Novolin)FDA Link 01/2020 - 01/2015
2	Tamoxifen FDA LinkGeneric 01/2020 - 10/2015
2	Fulvestrant (Faslodex)FDA Link 01/2020 - 01/2020
2	ChemokinesIBA 11/2018 - 11/2010
2	AntibodiesIBA 01/2017 - 11/2012
2	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 06/2015 - 05/2010
2	CarcinogensIBA 04/2015 - 06/2011
2	sodium sulfate (sodium bisulfate)FDA LinkGeneric 04/2014 - 11/2010
2	AzoxymethaneIBA 04/2014 - 11/2010
2	Sulindac (Copal)FDA LinkGeneric 01/2014 - 11/2010
2	Amino Acids FDA Link 07/2012 - 06/2002
2	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 11/2010 - 02/2006
2	Cyclin D1IBA 10/2010 - 08/2005
2	Gamma Secretase Inhibitors and ModulatorsIBA 11/2005 - 06/2005

Therapy/Procedure

47	Therapeutics 03/2024 - 11/2005
15	Drug Therapy (Chemotherapy) 01/2024 - 07/2011
11	Precision Medicine 01/2024 - 07/2013
6	Immunotherapy 03/2024 - 01/2018
6	Transplantation 01/2020 - 07/2012
2	Radiotherapy 01/2023 - 10/2019
2	Neoadjuvant Therapy 01/2023 - 01/2020
2	Heterologous Transplantation (Xenotransplantation) 01/2021 - 05/2015
2	Chemoprevention 01/2014 - 11/2010